L’annexe du règlement (CE) no 440/2008 est modifiée comme suit:
1) Avant la partie A, la partie 0 suivante est insérée:
«PARTIE 0
MÉTHODES D’ESSAI INTERNATIONALES RECONNUES COMME ÉTANT APPROPRIÉES POUR PRODUIRE DES INFORMATIONS SUR LES PROPRIÉTÉS INTRINSÈQUES DES SUBSTANCES AUX FINS DU RÈGLEMENT (CE) No 1907/2006
TABLEAU 1: MÉTHODES D’ESSAI POUR LA DÉTERMINATION DES PROPRIÉTÉS PHYSICO-CHIMIQUES DES SUBSTANCES
| Effet mesuré | Méthode d’essai | Chapitre correspondant, contenant la description complète de la méthode d’essai, dans la partie A de la présente annexe (les références entre parenthèses indiquent que la description complète de la méthode d’essai a été supprimée de la partie A; cellule vide: aucune méthode d’essai correspondante ne figure dans la partie A de la présente annexe)
| Point de fusion/point de congélation | OECD Test Guideline 102: Melting Point/Melting Range (1995) | A.1
| Point d’ébullition | OECD Test Guideline 103: Boiling point (1995) | A.2
| Densité | OECD Test Guideline 109: Density of Liquids and Solids (2012) | (A.3)
| Pression de vapeur | OECD Test Guideline 104: Vapour Pressure (2006) | (A.4)
| Tension superficielle | OECD Test Guideline 115: Surface Tension of Aqueous Solutions (1995) | A.5
| Solubilité dans l’eau | OECD Test Guideline 105: Water Solubility (1995) | A.6
| Coefficient de partage (n-octanol/eau) | OECD Test Guideline 107: Partition Coefficient (n-octanol/water): Shake-Flask Method (1995) | (A.8)
| OECD Test Guideline 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method (2022) | A.23
| OECD Test Guideline 117: Partition Coefficient (n-octanol/water): HPLC Method (2022) | A.24
| Constante de dissociation | OECD Test Guideline 112: Dissociation Constants in Water. (1981) | A.25
| Viscosité | OECD Test Guideline 114: Viscosity of Liquids (2012) |
| Point d’éclair | Test methods according to table 2.6.3 of Annex I, Part 2 of Regulation (EC) No 1272/2008 |
| Limites inférieure et supérieure d’explosivité | EN 1839:2017 – Determination of the explosion limits and the limiting oxygen concentration (LOC) for flammable gases and vapours |
| Inflammabilité | Test methods according to section 2.2.4.1. of Annex I, Part 2 of Regulation (EC) No 1272/2008 |
| Test L.2: sustained combustibility test, Part III, section 32 of the UN RTDG Manual of Tests and Criteria |
| Test N.1: test method for readily combustible solids, Part III, sub-section 33.2.4 of the UN RTDG Manual of Tests and Criteria |
| Test N.5: test method for substances which in contact with water emit flammable gases, Part III, sub-section 33.5.4 of the UN RTDG Manual of Tests and Criteria |
| Température d’inflammation spontanée (solides) | Test N.4: test method for self-heating substances, Part III, sub-section 33.4.6 of the UN RTDG Manual of Tests and Criteria |
| EN 15188:2020 – Determination of the spontanous ignition behaviour of dust accumulations |
| Température d’inflammation spontanée (liquides, gaz) | ISO/IEC 80079-20-1:2017 – Explosive atmospheres - Part 20-1: Material characteristics for gas and vapour classification - Test methods and data |
| Température de décomposition | Test Series H, part II, section 28, of the UN RTDG Manual of Tests and Criteria |
| Propriétés explosives | Test methods according to Test series 1-3, Part I, sections 11-13 of the UN RTDG Manual of Tests and Criteria |
| EU Test method A.14 Explosive Properties | A.14
| Propriétés comburantes | Test method according to section 2.4.4. of Annex I, Part 2 of Regulation (EC) No 1272/2008 |
| Test O.2: test for oxidizing liquids, Part III, sub-section 34.4.2 of the UN RTDG Manual of Tests and Criteria |
| Test O.1: Test for oxidizing solids, Part III, sub-section 34.4.1 of the UN RTDG Manual of Tests and Criteria |
| Test O.3 Gravimetric test for oxidizing solids, Part III, sub-section 34.4 3 of the UN RTDG Manual of Tests and Criteria |
| Propriétés pyrophoriques | Test N.3: test method for pyrophoric liquids, Part III, sub-section 33.3.1.5 of the UN RTDG Manual of Tests and Criteria |
| Test N.2: test method for pyrophoric solids, Part III, sub-section 33.3.1.4 of the UN RTDG Manual of Tests and Criteria |
| Granulométrie/caractéristiques des particules | EU test method A.22. Length Weighted Geometric Mean Diameter of Fibres | A.22
| ISO 13318 - Determination of Particle Size Distribution by Centrifugal Liquid Sedimentation Methods |
| ISO 21501 - Determination of Particle Size Distribution - Single Particle Light Interaction Methods |
| OECD Test Guideline 124: Determination of the Volume Specific Surface Area of Manufactured Nanomaterials (2022) |
| OECD Test Guideline 125: Particle Size and Particle Size Distribution of Nanomaterials (2022) |
| pH | OECD Test Guideline 122: Determination of pH, Acidity and Alkalinity (2013) |
| Propriétés des polymères | OECD Test Guideline 118: Determination of the Number-Average Molecular Weight and the Molecular Weight Distribution of Polymers using Gel Permeation Chromatography (1996) | A.18
| OECD Test Guideline 119: Determination of the Low Molecular Weight Content of a Polymer Using Gel Permeation Chromatography (1996) | A.19
| OECD Test Guideline 120: Solution/Extraction Behaviour of Polymers in Water (2000) | (A.20)
TABLEAU 2: MÉTHODES D’ESSAI POUR LA DÉTERMINATION DES PROPRIÉTÉS TOXICOLOGIQUES
| Effet mesuré | Méthode d’essai | Chapitre correspondant, contenant la description complète de la méthode d’essai, dans la partie B de la présente annexe (les références entre parenthèses indiquent qu’un chapitre contenant la description complète de la méthode d’essai a été supprimé de la partie B; cellule vide: aucune méthode d’essai correspondante ne figure dans la partie B de la présente annexe)
| Irritation/corrosion cutanée | In vitro:
| OECD Test Guideline 430: In vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER) (2015) | B.40
| OECD Test Guideline 431: In vitro Skin Corrosion: Reconstructed Human Epidermis (RhE) Test Method (2019) | (B.40 bis)
| OECD Test Guideline 435: In vitro Membrane Barrier Test Method for Skin Corrosion (2015) | B.65
| OECD Test Guideline 439: In vitro Skin Irritation: Reconstructed Human Epidermis Test Method (2021) | (B.46)
| In vivo:
| OECD Test Guideline 404: Acute Dermal Irritation/Corrosion (2015) | B.4
| Lésions oculaires graves/irritation oculaire | In vitro:
| OECD Test Guideline 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2020) | (B.47)
| OECD Test Guideline 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2018) | (B.48)
| OECD Test Guideline 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants (2017) | (B.61)
| OECD Test Guideline 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2020) | (B.68)
| OECD Test Guideline 492: Reconstructed Human Cornea-Like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2019) | (B.69)
| OECD Test Guideline 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification (2022) |
| OECD Test Guideline 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage (2021) |
| OECD Test Guideline 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage (2019) |
| OECD Test Guideline 467: Defined Approaches for Serious Eye Damage and Eye Irritation (2022) |
| In vivo:
| OECD Test Guideline 405: Acute Eye Irritation/Corrosion (2021) | (B.5)
| Sensibilisation cutanée | In vitro:
| OECD Test Guideline 442C: In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA) (2022) | (B.59)
| OECD Test Guideline 442D: In Vitro Skin Sensitisation Assays Addressing the AOP Key Event on Keratinocyte Activation (2022) | (B.60)
| OECD Test Guideline 442E: In Vitro Skin Sensitisation: In Vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation (2022) | (B.71)
| OECD Test Guideline 497: Defined Approaches on Skin Sensitisation (2021) |
| In vivo:
| OECD Test Guideline 429: Skin Sensitisation - Local Lymph Node Assay (2010) | B.42
| OECD Test Guideline 442A: Skin Sensitisation - Local Lymph Node Assay: DA (2010) | B.50
| OECD Test Guideline 442B: Skin Sensitisation - Local Lymph Node Assay: BrdU-ELISA or –FCM (2018) | (B.51)
|
OECD Test Guideline 406: Skin Sensitisation Guinea Pig
Maximisation Test and Buehler Test (2022)
| (B.6)
| Mutagénicité | In vitro:
| OECD Test Guideline 471: Bacterial Reverse Mutation Test (2020) | (B.13/14)
| OECD Test Guideline 476: In Vitro Mammalian Cell Gene Mutation Test Using the Hprt and xprt Genes (2016) | (B.17)
| OECD Test Guideline 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene (2016) | B.67
| OECD Test Guideline 473: In vitro Mammalian Chromosome Aberration Test (2016) | B.10
| OECD Test Guideline 487. In vitro Mammalian Cell Micronucleus Test (2016) | B.49
| In vivo:
| OECD Test Guideline475: Mammalian Bone Marrow Chromosome Aberration Test (2016) | B.11
| OECD Test Guideline474: Mammalian Erythrocyte Micronucleus Test (2016) | B.12
| OECD Test Guideline 483: Mammalian Spermatogonial Chromosome Aberration Test (2016) | B.23
| OECD Test Guideline 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays (2022) | (B.58)
| OECD Test Guideline 489: In Vivo Mammalian Alkaline Comet Assay (2016) | B.62
| OECD Test Guideline 470: Mammalian Erythrocyte Pig-a Gene mutation Assay (2022) |
| Toxicité aiguë | Oral:
| OECD Test Guideline 420: Acute Oral Toxicity: Fixed Dose Procedure (2002) | B.1 bis
| OECD Test Guideline 423: Acute Oral Toxicity: Acute Toxic Class Method (2002) | B.1 tris
| OECD Test Guideline 425: Acute Oral Toxicity: Up-and-Down Procedure (2022) |
| Dermal:
| OECD Test Guideline 402: Acute Dermal Toxicity - Fixed Dose Procedure (2017) | (B.3)
| Inhalation:
| OECD Test Guideline 403: Acute Inhalation Toxicity (2009) | B.2
| OECD Test Guideline 436: Acute Inhalation Toxicity - Acute Toxic Class Method (2009) | B.52
| OECD Test Guideline 433: Acute Inhalation Toxicity: Fixed Concentration Procedure (2018) |
| Toxicité par administration répétée | OECD Test Guideline 407: Repeated Dose 28-Day Oral Toxicity Study in Rodents (2008) | B.7
| OECD Test Guideline 412: Subacute Inhalation Toxicity: 28-Day Study (2018) | (B.8)
| OECD Test Guideline 410: Repeated Dose Dermal Toxicity: 21/28-Day Study (1981) | B.9
| OECD Test Guideline 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (2016) | B.64
| OECD Test Guideline 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents (2018) | (B.26)
| OECD Test Guideline 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents (1998) | B.27
| OECD Test Guideline 413: Subchronic Inhalation Toxicity: 90-Day Study (2018) | (B.29)
| OECD Test Guideline 411: Subchronic Dermal Toxicity: 90-Day Study (1981) | B.28
| OECD Test Guideline 452: Chronic Toxicity Studies (2018) | (B.30)
| OECD Test Guideline 453: Combined Chronic Toxicity/Carcinogenicity Studies (2018) | (B.33)
| Toxicité pour la reproduction/le développement | OECD Test Guideline 443: Extended One-Generation Reproduction Toxicity Study (2018) | (B.56)
| OECD Test Guideline 421: Reproduction/Developmental Toxicity Screening Test (2016) | B.63
| OECD Test Guideline 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test (2016) | B.64
| OECD Test Guideline 414: Prenatal Developmental Toxicity Study (2018) | (B.31)
| Toxicocinétique | OECD Test Guideline 417: Toxicokinetics (2010) | B.36
| OECD Test Guideline 428: Skin Absorption: In Vitro Method (2004) | B.45
| OECD Test Guideline 427: Skin Absorption: In Vivo Method (2004) | B.44
| Cancérogénicité | OECD Test Guideline 451: Carcinogenicity Studies (2018) | (B.32)
| OECD Test Guideline 453: Combined Chronic Toxicity/Carcinogenicity Studies (2018) | (B.33)
| EU test method B.21. In Vitro Mammalian Cell Transformation Test | B.21
| Neurotoxicité (pour le développement) | OECD Test Guideline 424: Neurotoxicity Study in Rodents (1997) | B.43
| OECD Test Guideline 426: Developmental Neurotoxicity Study (2007) | B.53
| OECD Test Guideline 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure (1995) | B.37
| OECD Test Guideline 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study (1995) | B.38
| Propriétés de perturbation endocrinienne | In vitro
| OECD Test Guideline 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonistsals (2021) | (B.66)
| OECD Test Guideline 456: H295R Steroidogenesis Assay (2022) | B.57
| OECD Test Guideline 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals (2020) |
| OECD Test Guideline 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity (2015) | B.70
| In vivo
| OECD Test Guideline 440: Uterotrophic Bioassay in Rodents A short-term screening test for oestrogenic properties (2007) | B.54
| OECD Test Guideline 441: Hershberger Bioassay in Rats, A Short-term Screening Assay for (Anti)Androgenic Properties (2009) | B.55
| Phototoxicité | OECD Test Guideline 432: In Vitro 3T3 NRU Phototoxicity Test (2019) | (B.41)
| OECD Test Guideline 495: Ros (Reactive Oxygen Species) Assay for Photoreactivity (2019) |
| OECD Test Guideline 498: In Vitro Phototoxicity Test Method Using the Reconstructed Human Epidermis (RhE) (2021) |
TABLEAU 3: MÉTHODES D’ESSAI POUR LA DÉTERMINATION DES PROPRIÉTÉS ÉCOTOXICOLOGIQUES
| Effet mesuré | Méthode d’essai | Chapitre correspondant, contenant la description complète de la méthode d’essai, dans la partie C de la présente annexe (les références entre parenthèses indiquent qu’un chapitre contenant la description complète de la méthode d’essai a été supprimé de la partie C; cellule vide: aucune méthode d’essai correspondante ne figure dans la partie C de la présente annexe)
| Toxicité pour le milieu aquatique | OECD Test Guideline 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test (2011) | C.3
| OECD Test Guideline 209: Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation) (2010) | C.11
| OECD Test Guideline 224: Determination of the Inhibition of the Activity of Anaerobic Bacteria (2007) | C.34
| OECD Test Guideline 244: Protozoan Activated Sludge Inhibition Test (2017) |
| OECD Test Guideline 221: Lemna sp. Growth Inhibition Test (2006) | C.26
| OECD Test Guideline 202: Daphnia sp. Acute Immobilisation Test (2004) | C.2
| OECD Test Guideline 211: Daphnia magna Reproduction Test (2012) | C.20
| OECD Test Guideline 203: Fish, Acute Toxicity Test (2019) | (C.1)
| OECD Test Guideline 210: Fish, Early-life Stage Toxicity Test (2013) | C.47
| OECD Test Guideline 215: Fish, Juvenile Growth Test (2000) | C.14
| OECD Test Guideline 236: Fish Embryo Acute Toxicity (FET) Test (2013) | C.49
| OECD Test Guideline 249: Fish Cell Line Acute Toxicity - the RTgill-W1 Cell Line Assay (2021) |
| OECD Test Guideline 242: Potamopyrgus antipodarum Reproduction Test (2016) |
| OECD Test Guideline 243: Lymnaea stagnalis Reproduction Test (2016) |
| Dégradation | OECD Test Guideline 111: Hydrolysis as a Function of pH (2004) | C.7
| OECD Test Guideline 301: Ready Biodegradability (1992) | C.4
| OECD Test Guideline 302A: Inherent Biodegradability: Modified SCAS Test (1981) | C.12
| OECD Test Guideline 302B: Inherent Biodegradability: Zahn-Wellens/EMPA Test (1992) | (C.9)
| OECD Test Guideline 302C: Inherent Biodegradability: Modified MITI Test (II) (2009) |
| OECD Test Guideline 303: Simulation Test - Aerobic Sewage Treatment -- A: Activated Sludge Units; B: Biofilms (2001) | C.10
| OECD Test Guideline 304A: Inherent Biodegradability in Soil (1981) |
| OECD Test Guideline 306: Biodegradability in Seawater (1992) | C.42
| OECD Test Guideline 307: Aerobic and Anaerobic Transformation in Soil (2002) | C.23
| OECD Test Guideline 308: Aerobic and Anaerobic Transformation in Aquatic Sediment Systems (2002) | C.24
| OECD Test Guideline 309: Aerobic Mineralisation in Surface Water – Simulation Biodegradation Test (2004) | C.25
| OECD Test Guideline 310: Ready Biodegradability - CO2 in sealed vessels (Headspace Test) (2014) | C.29
| OECD Test Guideline 311: Anaerobic Biodegradability of Organic Compounds in Digested Sludge: by Measurement of Gas Production (2006) | C.43
| OECD Test Guideline 314: Simulation Tests to Assess the Biodegradability of Chemicals Discharged in Wastewater (2008) |
| OECD Test Guideline 316: Phototransformation of Chemicals in Water – Direct Photolysis (2008) |
| EU test method C.5. Degradation – Biochemical Oxygen Demand | C.5
| EU test method C.6. Degradation – Chemical Oxygen Demand | C.6
| Devenir et comportement dans l’environnement | OECD Test Guideline 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure (2012) | C.13
| OECD Test Guideline 315: Bioaccumulation in Sediment-Dwelling Benthic Oligochaetes (2008) | C.46
| OECD Test Guideline 317: Bioaccumulation in Terrestrial Oligochaetes (2010) | C.30
| OECD Test Guideline 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media (2017) |
| OECD Test Guideline 121: Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC) (2001) | C.19
| OECD Test Guideline 106: Adsorption - Desorption Using a Batch Equilibrium Method (2000) | C.18
| OECD Test Guideline 312: Leaching in Soil Columns (2004) | C.44
| OECD Test Guideline 313: Estimation of Emissions from Preservative - Treated Wood to the Environment (2007) | C.45
| OECD Test Guideline 319A: Determination of In Vitro Intrinsic Clearance Using Cryopreserved Rainbow Trout Hepatocytes (RT-HEP) (2018) |
| OECD Test Guideline 319B: Determination of In Vitro Intrinsic Clearance Using Rainbow Trout Liver S9 Sub-Cellular Fraction (RT-S9) (2018) |
| OECD Test Guideline 320: Anaerobic Transformation of Chemicals in Liquid Manure (2022) |
| Effets sur les organismes terrestres | OECD Test Guideline 216: Soil Microorganisms: Nitrogen Transformation Test (2000) | C.21
| OECD Test Guideline 217: Soil Microorganisms: Carbon Transformation Test (2000) | C.22
| OECD Test Guideline 207: Earthworm, Acute Toxicity Tests (1984) | C.8
| OECD Test Guideline 222: Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei) (2016) | (C.33)
| OECD Test Guideline 220: Enchytraeid Reproduction Test (2016) | (C.32)
| OECD Test Guideline 226: Predatory Mite (Hypoaspis (Geolaelaps) aculeifer) Reproduction Test in Soil (2016) | (C.36)
| OECD Test Guideline 232: Collembolan Reproduction Test in Soil (2016) | (C.39)
| OECD Test Guideline 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test (2006) | C.31
| OECD Test Guideline 227: Terrestrial Plant Test: Vegetative Vigour Test (2006) |
| Effets sur les organismes présents dans les sédiments | OECD Test Guideline 218: Sediment-Water Chironomid Toxicity Using Spiked Sediment (2004) | C.27
| OECD Test Guideline 219: Sediment-Water Chironomid Toxicity Using Spiked Water (2004) | C.28
| OECD Test Guideline 233: Sediment-Water Chironomid Life-Cycle Toxicity Test Using Spiked Water or Spiked Sediment (2010) | C.40
| OECD Test Guideline 235: Chironomus sp., Acute Immobilisation Test (2011) |
| OECD Test Guideline 225: Sediment-Water Lumbriculus Toxicity Test Using Spiked Sediment (2007) | C.35
| OECD Test Guideline 238: Sediment-Free Myriophyllum Spicatum Toxicity Test (2014) | C.50
| OECD Test Guideline 239: Water-Sediment Myriophyllum Spicatum Toxicity Test (2014) | C.51
| Effets sur les oiseaux | OECD Test Guideline 205: Avian Dietary Toxicity Test (1984) |
| OECD Test Guideline 206: Avian Reproduction Test (1984) |
| OECD Test Guideline 223: Avian Acute Oral Toxicity Test (2016) |
| Effets sur les insectes | OECD Test Guideline 213: Honeybees, Acute Oral Toxicity Test (1998) | C.16
| OECD Test Guideline 214: Honeybees, Acute Contact Toxicity Test (1998) | C.17
| OECD Test Guideline 237: Honey Bee (Apis Mellifera) Larval Toxicity Test, Single Exposure (2013) |
| OECD Test Guideline 245: Honey Bee (Apis Mellifera L.), Chronic Oral Toxicity Test (10-Day Feeding) (2017) |
| OECD Test Guideline 246: Bumblebee, Acute Contact Toxicity Test (2017) |
| OECD Test Guideline 247: Bumblebee, Acute Oral Toxicity Test (2017) |
| OECD Test Guideline 228: Determination of Developmental Toxicity to Dipteran Dung Flies (Scathophaga stercoraria L. (Scathophagidae), Musca autumnalis De Geer (Muscidae)] (2016) |
| Propriétés de perturbation endocrinienne | OECD Test Guideline 230: 21-Day Fish Assay (2009) | C.37
| OECD Test Guideline 229: Fish Short Term Reproduction Assay (2012) | C.48
| OECD Test Guideline 231: Amphibian Metamorphosis Assay (2009) | C.38
| OECD Test Guideline 234: Fish Sexual Development Test (2011) | C.41
| OECD Test Guideline 240: Medaka Extended OneGeneration Reproduction Test (MEOGRT) (2015) | C.52
| OECD Test Guideline 241: The Larval Amphibian Growth and Development Assay (LAGDA) (2015) | C.53»
| OECD Test Guideline 248: Xenopus Eleutheroembryonic Thyroid Assay (XETA) (2019) |
| OECD Test Guideline 250: EASZY assay - Detection of Endocrine Active Substances, Acting Through Estrogen Receptors, Using Transgenic tg(cyp19a1b:GFP) Zebrafish embrYos (2021) |
| OECD Test Guideline 251: Rapid Androgen Disruption Activity Reporter (RADAR) Assay (2022)» |
2) Dans la partie A, le texte sous le titre de chacun des chapitres A.3, A.4, A.8 à A.12, A.15 à A.17, A.20 et A.21 est remplacé par le texte suivant: «La description complète de cette méthode d’essai a été supprimée. La méthode d’essai internationale équivalente, ou d’autres méthodes d’essai applicables pour mesurer l’effet considéré figurent dans le tableau 1 de la partie 0.».
3) Dans la partie B, le texte sous le titre de chacun des chapitres B.3, B.5, B.6, B.8, B.13/14, B.17, B.26, B.29 à B.33, B.40 bis, B.41, B.46 à B.48, B.51, B.56, B.58 à B.61, B.66, B.68, B.69 et B.71 est remplacé par le texte suivant: «La description complète de cette méthode d’essai a été supprimée. La méthode d’essai internationale équivalente figure dans le tableau 2 de la partie 0.»
4) Dans la partie B, le texte sous le titre de chacun des chapitres B.22, B.25, B.34, B.35. et B.39 est remplacé par le texte suivant: «Cette méthode d’essai a été supprimée car elle n’est plus reconnue comme étant appropriée pour produire des informations sur les propriétés toxicologiques des substances chimiques aux fins du règlement (CE) no 1907/2006. Les méthodes d’essai applicables pour mesurer l’effet considéré figurent dans le tableau 2 de la partie 0.».
5) Dans la partie C, le texte sous le titre de chacun des chapitres C.1, C.9, C.32, C.33, C.36 et C.39 est remplacé par le texte suivant: «La description complète de cette méthode d’essai a été supprimée. La méthode d’essai internationale équivalente figure dans le tableau 3 de la partie 0.».
6) Dans la partie C, le texte sous le titre du chapitre C.15 est remplacé par le texte suivant: «Cette méthode d’essai a été supprimée car elle n’est plus reconnue comme étant appropriée pour produire des informations sur les propriétés écotoxicologiques des substances chimiques aux fins du règlement (CE) no 1907/2006. Les méthodes d’essai applicables pour mesurer l’effet considéré figurent dans le tableau 3 de la partie 0.».